Abstract: Objective：To study the changes of the plasma rennin activity (PRA), aldosterone (ALD) and aldosterone/rennin ratio (ARR) in response to posture test alone or posture-furosemide test (double stimulation) in patients confirmed with aldsterone-producing adenoma (APA). Methods：Retrospective chart review was conducted in a total of 112 APA patients who were confirmed by surgery and postoperative biopsy. Posture test alone was performed in 60 patients, and posture-furosemide test was done in 52 patients before surgery. Clinical characteristics, PRA, ALD, and ARR were compared. Results：No significant differences were observed between the two groups in clinical characteristics, PRA, ALD or ARR, whereas the frequency of side-effect related to the tests was higher in the group using double-stimulation. Conclusion：There isn’t much difference whether furosemide is added to posture test for the evaluation of APA, it may increase side-effects instead.