目的 探讨广东梅县地区痛风患者生活方式、临床特征及痛风反复发作的影响因素。方法 收集188例广东梅县地区痛风患者的人口学数据、生活方式、临床资料。使用Logistic回归分析痛风发作次数增多的因素。结果 188例痛风患者中,男性占91%,年龄（50±16）岁,有饮酒史者占50%,喜爱食用海鲜等高嘌呤食物者占31%,每日饮水量少于1 000 ml者占79%,无运动习惯者占72%。首次痛风发作发生在第一跖趾关节者占30.3%,且有46.3%者出现于身体右侧。痛风石数目0 ~ 21个/例,其中6例出现在足趾关节。38%患者有超过20次痛风发作。Logistic回归分析显示痛风发作次数超过20次与年龄（OR=1.052, 95%CI 1.024 ~ 1.081）、饮水量少于1 500 ml/d（OR =4.125,95%CI 1.437 ~ 11.843）、病程 （OR = 1.001,95%CI 1.000 ~ 1.002）和血尿酸水平（OR = 1.009,95%CI 1.006 ~ 1.012）呈正相关（P均< 0.05）。结论 广东梅县地区痛风患者以男性为主,存在喜爱饮酒、高嘌呤食物、饮水少等不良生活习惯。痛风发作次数与年龄、饮水量少、病程及血尿酸水平有关。

Objective To explore the lifestyle, clinical features and risk factors of recurrent gout attacks in patients with gout from Meixian, Guangdong Province. Methods Demographic data, lifestyle and clinical data of 188 patients with gout in Meixian, Guangdong province were collected. Logistic regression analysis was utilized to analyze the risk factors of increased gout attacks. Results Among 188 gout patients, 171 （91.0%） cases were male and 17 （9.0%） were female, aged （55±16） years on average. Ninety-four （50%） of them had a habit of drinking alcohol, 31% frequent intake of seafood and other high-purine food, 79% had water intake of < 1 000 ml/d and 72% failed to take exercise on a regular basis. The first gout attack occurred in the first metatarsophalangeal joint of 57 （30.3%） cases. The first gout attack occurred on the right side of 87 （46.3%） cases. The number of tophus was ranged from 0 to 21 per person. The tophus was observed in the toe joints of 6 （54.5%） cases. Sixty-four （38.1%） patients experienced more than 20 gout attacks. Logistic regression analysis revealed that the incidence of > 20 gout attacks was positively correlated with age （OR = 1.052, 95%CI 1.024-1.081）, water intake less than 1 500 ml/d （OR = 4.125, 95%CI 1.437-11.843）,disease duration （OR = 1.001, 95%CI 1.000-1.002） and uric acid level （OR = 1.009, 95%CI 1.006-1.012）, all P < 0.05. Conclusions A majority of gout patients are male in Meixian, Guangdong Province. They have unhealthy lifestyles, such as drinking alcohol, frequent intake of hyperpurine food and lack of drinking water. The frequency of gout attack is positively correlated with age, insufficient water intake, disease duration and uric acid level.