Objective：To investigate the influence of combined ultrasound-guided follicle puncture technique and metformin on insulin resistance, ovary rate (OR), pregnancy rate in clomifene-resistant polycystic ovarian syndrome (PCOS) women. Methods：Sixty-six women with clomifene-resistant PCOS were divided into two groups. Combined group (n=33) was given combined therapy of oral metformin and ultrasound-guided follicle puncture. Simple group (n=33) was given ultrasound-guided follicle puncture alone. Insulin resistance and ovary rate were investigated after therapy and the normal pregnancy rate was also investigated. Results：The ovulating rates in both groups significantly increased after treatment (P<0.01). There was no significant differences in the index of insulin resistanc between pre- and post-treatment in simple group. The index of insulin saitivity of combined group had significant improvement compared to simple group (P<0.05), while the index of insulin resistance significantly decreased(P<0.05). there="" was="" no="" significant="" differences="" in="" or="" between="" the="" two="" groups="" after="" treatment="" p="">0.05). The pregnancy rate （39%）of combined group was significantly higher than that（24%）of simple group(P<0.05). Conclusions： Metformin combined with ultrasound-guided puncture technique can increase OR, improve insulin resistance and increase pregnancy rate in clomifene-resistant PCOS women.
