目的 评价六氟化硫微泡造影剂应用于高强度聚焦超声（HIFU）治疗子宫腺肌病中的临床价值。方法 选取行HIFU治疗的70例子宫腺肌病患者作为研究对象,随机分为研究组和对照组,研究组HIFU治疗术前及术后应用六氟化硫微泡造影,对照组术前不应用六氟化硫微泡造影,术后造影。对比2组患者治疗时间、高能聚焦时间、出现团块时间、病灶消融率以及并发症发生率,并分析2组患者治疗后子宫体积、腺肌病灶体积、月经量、经期的差异。结果 研究组治疗时间、高能聚焦时间、出现团块时间分别为（86.40±23.17）min、（985.03±113.06）s、（812.34±197.63）s,对照组分别为（122.11±26.33）min、（1195.60± 181.55）s、（1100.40± 242.77）s,研究组治疗时间、高能聚焦时间及出现团块时间均短于对照组（P均< 0.05）。研究组病灶消融率为（83.92±5.07）%,对照组为（82.92±5.36）%,组间比较差异无统计学意义（P > 0.05）。研究组1例术后发生下腹痛,并发症发生率为3%。对照组发生下腹痛4例、骶尾部疼痛2例、皮肤烫伤2例,并发症发生率为23%,研究组并发症发生率低于对照组（P < 0.05）。研究组与对照组HIFU治疗后子宫体积、腺肌病灶体积、月经量、经期比较差异均无统计学意义（P均> 0.05）。结论 应用HIFU治疗子宫腺肌病时,术前应用六氟化硫微泡造影可缩短治疗时间及减少并发症的发生。

Objective To evaluate the clinical value of sulfur hexafluoride microbubbles in the high-intensity focused ultrasound （HIFU） treatment of uterine adenomyosis.Methods Seventy patients with uterine adenomyosis treated with HIFU were recruited and randomly divided into the experimental and control groups. Before and after HIFU treatment, sulfur hexafluoride microbubble-ultrasonography was given in the experimental group, whereas sulfur hexafluoride microbubble-ultrasonography was delivered after HIFU treatment in the control group. The treatment time, high-energy focusing time, agglomerating time, ablation rate and complication rate were compared between two groups. After corresponding treatment, the uterine volume, adenomyosis volume, menstrual volume and menstrual period were statistically analyzed between two groups.Results In the experimental group, the treatment time, high-energy focusing time and agglomerating time were （86.40±23.17） min, （985.03±113.06） s and （812.34±197.63） s, significantly shorter compared with （122.11±26.33） min, （1195.60±181.55） s and （1100.40±242.77） s in the control group （all P < 0.05）. The ablation rates did not significantly differ between the experimental and control groups （83.92±5.07）% vs. （82.92±5.36）%, P > 0.05. In the experimental group, 1 case had lower abdominal pain with an incidence rate of 3%. In the control group, 4 patients experienced lower abdominal pain, 2 cases of sacrococcygeal pain and 2 cases of skin scald with an incidence rate of 23%, significantly higher than 3% in the experimental group （P < 0.05）. The uterine volume, adenomyosis volume, menstrual volume and menstrual period did not significantly differ between two groups （all P > 0.05）.Conclusion Application of sulfur hexafluoride microbubble-ultrasonography prior to HIFU can shorten the treatment time and reduce the incidence of complications.