Objective:To investigate the current status of caries and analyze the risk factors associated with caries in 12~13-year-old children in Guangzhou. Methods:Multistage stratified cluster random sampling method was used to obtain 1500 samples among 12~13-year-old children in Guangzhou. The caries on the crowns of permanent teeth were examined. The questionnaire included demographics data, oral health behaviors, etc. The prevalence of caries and mean-DMFT was analyzed by descriptive analysis. Logistic regression analysis was used to explore the factors associated with caries. Results:The prevalence of caries was 24.47%, with a mean DMFT of 0.488, SiC was 1.46. 75.27% of the caries teeth had been not given dental treatments. Result of the logistic regression analysis showed that gender, Singleton or not, frequency of tooth brushing per day, whether or not liking eating sugar food, frequency of sugar beverages consumed per week, and liking eating hard food or not had a significant independent effect on caries. Conclusion:The data suggested that caries rate decreased and the rate of teeth of caries was filled increased, however, with most of the involved teeth had not treated. The child who was girl, non-singleton, brushing his teeth per day≤1 time, liking eating sugar food, frequency of sugar beverages consumed per week ≥1 time and not like eating hard food was focus on prevention of dental caries in Guangzhou.